Mkpa ọgwụgwọ
COVID-19 bụ ọrịa sitere na nje nje SARS-CoV-2 novel, nke na-etinye ma na-abanye n'ime sel ndị ọbịa site na protein ya.Ka ọ dị ugbu a, enwere ihe karịrị nde 138.3 edere n'ụwa niile, yana ọnụ ọgụgụ ndị nwụrụ na-eru nso nde atọ.
Ọ bụ ezie na akwadoro ọgwụ mgbochi maka iji ihe mberede mee ihe, a jụwo ịdị irè ha megide ụfọdụ ụdị ọhụrụ ahụ.Ọzọkwa, mkpuchi ịgba ọgwụ mgbochi ọrịa ma ọ dịkarịa ala 70% nke ndị bi na mba ụwa niile nwere ike were ogologo oge, n'ịtụle usoro ịgba ọgwụ mgbochi ọrịa ugbu a, ụkọ mmepụta ọgwụ mgbochi na ihe ịma aka mgbagha.
Ụwa ka ga-achọ ọgwụ ndị dị irè ma dị nchebe, ya mere, iji tinye aka na ọrịa siri ike nke nje a kpatara.Nyocha ugbu a na-elekwasị anya na onye ọ bụla na ọrụ synergistic nke curcumin na nanostructures megide nje.

Mkpa ọgwụgwọ
COVID-19 bụ ọrịa sitere na nje nje SARS-CoV-2 novel, nke na-etinye ma na-abanye n'ime sel ndị ọbịa site na protein ya.Ka ọ dị ugbu a, enwere ihe karịrị nde 138.3 edere n'ụwa niile, yana ọnụ ọgụgụ ndị nwụrụ na-eru nso nde atọ.
Ọ bụ ezie na akwadoro ọgwụ mgbochi maka iji ihe mberede mee ihe, a jụwo ịdị irè ha megide ụfọdụ ụdị ọhụrụ ahụ.Ọzọkwa, mkpuchi ịgba ọgwụ mgbochi ọrịa ma ọ dịkarịa ala 70% nke ndị bi na mba ụwa niile nwere ike were ogologo oge, n'ịtụle usoro ịgba ọgwụ mgbochi ọrịa ugbu a, ụkọ mmepụta ọgwụ mgbochi na ihe ịma aka mgbagha.
Ụwa ka ga-achọ ọgwụ ndị dị irè ma dị nchebe, ya mere, iji tinye aka na ọrịa siri ike nke nje a kpatara.Nyocha ugbu a na-elekwasị anya na onye ọ bụla na ọrụ synergistic nke curcumin na nanostructures megide nje.

Curcumin
Curcumin bụ ngwakọta polyphenolic dịpụrụ adịpụ na rhizome nke osisi turmeric, Curcuma longa.Ọ na-eme curcuminoid bụ isi na osisi a, na 77% nke mkpokọta, ebe obere curcumin II mejupụtara 17% na curcumin III nwere 3%.
A mara curcumin ma mụọ ya nke ọma, dị ka mkpụrụ ndụ eke nwere ihe eji eme ọgwụ.Edekọla nnabata ya na nchekwa ya nke ọma, yana oke oke nke 12 g / ụbọchị.
A kọwawo ojiji ya dị ka mgbochi mkpali, anticancer, na antioxidant, yana mgbochi nje.Atụpụtala curcumin ka ọ bụrụ mkpụrụ ndụ nwere ikike ịgwọ edema akpa ume na usoro ndị ọzọ na-emerụ ahụ na-eduga na fibrosis nku ume na-eso COVID-19.

Curcumin na-egbochi enzymes viral
A na-eche na nke a bụ n'ihi ikike o nwere igbochi nje n'onwe ya, yana imezi ụzọ mkpali.Ọ na-ahazi transcript viral na ụkpụrụ, na-ejikọta ya na ike dị elu na viral main protease (Mpro) enzyme nke bụ isi ihe na-emegharị ma na-egbochi njikọ nje na ịbanye n'ime cell host.Ọ nwekwara ike ịkpaghasị ihe owuwu nje.
Ihe mgbochi ya gụnyere nje ịba ọcha n'anya C, nje immunodeficiency (HIV), nje Epstein-Barr na nje influenza A.Akọwo na ọ na-egbochi 3C-dị ka protease (3CLpro) nke ọma karịa ngwaahịa ndị ọzọ sitere n'okike, gụnyere quercetin, ma ọ bụ ọgwụ dị ka chloroquine na hydroxychloroquine.
Nke a nwere ike inye ohere ibelata ibu nje n'ime sel mmadụ ngwa ngwa karịa ọgwụ ndị ọzọ na-adịghị egbochi ya, wee si otú a gbochie ọrịa na-aga n'ihu na nnukwu nsogbu iku ume (ARDS).
Ọ na-egbochikwa papain-dị ka protease (PLpro) na ntinye 50% inhibitory (IC50) nke 5.7 µM nke karịrị quercetin na ngwaahịa ndị ọzọ sitere n'okike.

Curcumin na-egbochi nnabata cell nnabata
Nje virus na-ejikọta ya na onye na-anabata sel ndị na-anabata ya, angiotensin-converting enzyme 2 (ACE2).Ọmụmụ ihe nlere anya egosila na curcumin na-egbochi mmekọrịta nke ndị na-anabata nje a n'ụzọ abụọ, site na igbochi ma protein spike na onye na-anabata ACE2.
Otú ọ dị, curcumin nwere obere bioavailability, n'ihi na ọ naghị agbaze nke ọma na mmiri ma na-akwụsi ike na mgbasa ozi mmiri, karịsịa na pH dị elu.Mgbe a na-enye ya ọnụ, ọ na-enweta metabolism ngwa ngwa site na eriri afọ na imeju.Enwere ike imeri ihe mgbochi a site na iji nanosystems.
Enwere ike iji ọtụtụ ụgbọ nanostructured dị iche iche maka ebumnuche a, dị ka nanoemulsions, microemulsions, nanogels, micelles, nanoparticles na liposomes.Ndị na-ebu ndị dị otú ahụ na-egbochi mmebi nke metabolic nke curcumin, na-abawanye solubility ya ma nyere ya aka ịkwaga site na akpụkpọ anụ.
Ngwaahịa curcumin dabere na nanostructure atọ ma ọ bụ karịa adịlarị azụmaahịa, mana ọmụmụ ole na ole enyochala ịdị irè ha megide COVID-19 na vivo.Ndị a gosipụtara ikike nke usoro ahụ iji gbanwee nzaghachi mgbochi ọrịa na ibelata mgbaàmà nke ọrịa ahụ, na ikekwe mee ngwa ngwa mgbake.